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IMACEL Case Studies
Support Case#01
Phenotypic Screening ～Identifying candidate compounds via cell morphology analysis～
Challenge
Unlike conventional candidate compound screening methods that focus on a specific molecular target, phenotypic screening is a technique for identifying compounds that induce a desired phenotypic change in disease model cells. Its value is rapidly growing, driven by advancements in imaging and data analysis, and the use of living cells.
Effective phenotypic screening requires the recognition of individual cells and the precise evaluation of morphological changes following compound administration. Manual visual assessment, however, struggles to identify subtle changes or handle the massive volume of cells required for high-throughput analysis and evaluation.
LPIXEL’s Solution – AI Technology and Impact
LPIXEL has developed a machine learning model that recognizes cell nuclei at single-cell resolution, classifies cells into morphological groups, and quantifies the results.
This capability enables the precise quantitative evaluation of candidate compounds, making high-throughput screening possible by leveraging compound libraries of pharmaceutical companies.
In recent years, disease-specific iPS cells have also been utilized as disease model cells.
https://www.nature.com/articles/d43747-021-00042-w
https://www.nature.com/articles/d43747-021-00042-w
Support Case#01
Phenotypic Screening
～Identifying candidate compounds via cell morphology analysis～
Support Case#02
Automated fluorescent multiplex immunohistochemistry image analysis
～Applied to anticancer drug research and development (R&D) and spatial analysis of the tumor microenvironment.～
Support Case#03
Pathology specimen analysis
～Abnormality screening and virtual staining～
Support Case#04
Automated Light-Sheet Microscopy Image Analysis
～Automatic Brain Region Segmentation and Improved Efficiency in Perivascular Environment Analysis～
Support Case#05
Novel approaches to animal behaviour analysis using AI
～Advanced behavioural insights and precise quantification～
Support Case#06
Automated Micronucleus Test Evaluation
～Provided as an automatic analysis service～
Support Case#07
Automation of Chromosomal Abnormality Detection
～Applications in dose assessment and genotoxicity testing following radiation overexposure～
Support Case#08
Ice Crystal Analysis in the Freeze-Drying Process
～Optimizing Manufacturing Processes with AI～
Support Case#09
Lab Automation Support
～Integrating image-analysis AI into automated medium-scale synthesis systems～